Optimization in PythonLanguage is interesting, because it's a DynamicLanguage, so development is very fast but runtime performance is not so fast and optimizations are not obvious. In short, it supports Code First, OptimizeLater very well.
Python Patterns - An Optimization Anecdote by GuidoVanRossum
There is a paper somewhere on an optimization methodology of 'write everything in Python, then rewrite the critical bits in C' (AlternateHardAndSoftLayers), but I don't have a link.
Pyrex, IronPython, PsycoPython, BoostPythonLibrary, and of course simple embedded CeeLanguage or JavaLanguage (are you using cPython or JythonLanguage?).
Odd that I see pages "PythonOptimization" and "FasterJava",
but not one on C++ optimization.
Ah well, I'll put this here and let some overworked WikiGnome create FasterCpp?
(or else move it to some more appropriate page that I've overlooked).
Condescending, aren't we?
"C++ Optimization Strategies and Techniques"
by Pete Isensee, Xbox programmer at Microsoft